Based on a review of scholarly literature and statements of IAEA and Ukrainian institutions, we try to attempt to analyze the current problems in nuclear energy of Ukraine during the war based on the example of the seized Zaporizhzhia nuclear power plant, which demonstrates the impact of this situation over global nuclear safety. Our study also outlines some solutions to this ongoing crisis and highlights that there is an urgent need for a new strategic vision at the global level with regard to nuclear safety and environmental protection. The “trial and error” approach is not the desired practice of ensuring nuclear safety in the world and therefore the world must today apply the lessons learned during the war in Ukraine to better protect people and the environment. The current situation in the world is complex and requires reasonable considerations, taking into account social, economic, environmental and geopolitical aspects. The introduction of minimum International Atomic Energy Agency (IAEA) safety standards that are illegally enforceable, the revision of the provisions of the IAEA statute and its amendment by providing the organization with the function of maintaining the harmonization of nuclear requirements, the need to improve the existing IAEA standards in terms of taking measures during the construction of nuclear power plants to protect them from missile attacks, as well as during the operation of NPPs are all analyzed as necessary steps required to solve the issues of improving nuclear safety in Ukraine, Europe, and the world. The cooperation of Ukraine with such states as the USA, Japan, South Korea, France, and the United Kingdom, and the creation of the coalition could help to put pressure on United Nations and IAEA at the international level to withdraw all troops and ammunition supplies from Zaporizhzhia NPP.